DIPOTASSIUM GLYCYRRHIZINATE

Anti-aging Anti-aging Anti-inflammation Anti-inflammation Hair care Hair care Anti-acne Anti-acne UV UV Rough skin Rough skin Sensitive skin Sensitive skin From licorice From licorice Clinical data Clinical data HALAL HALAL COSMOS COSMOS

Realizing the differenceProtecting any skin type from daily stimuli

  • DIPOTASSIUM GLYCYRRHIZINATE

    Superior anti-inflammation agent, essential component of many cosmetic formulations.

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Mechanism

How barrier function affects skin appearance
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Focusing on "balance" of regulating factors

In healthy skin, the balance of factors related to nerve elongation is maintained with inhibitory factors predominating. However, it is known that in rough or sensitive skin, this balance is lost, and elongation factors become dominant.

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Product information

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Product name DIPOTASSIUM GLYCYRRHIZINATE
Scientific name Glycyrrhiza glabra L.
Glycyrrhiza uralensis Fisch. ex DC.
Glycyrrhiza inflata Batalin
Plant name (Japanese) 甘草(カンゾウ)
Part of use Licorice root
INCI JSQI name IECIC 2021 CAS#
Dipotassium Glycyrrhizate グリチルリチン酸ジカリウム 甘草酸二钾 1007893-70-0(68797-35-3)

Study

Clinical data

Preventing effect on stinging sensation

Effect of a single application of cream with 0.2% DIPOTASSIUM GLYCYRRHIZINATE to relieve sensory stimulation (lactic acid stimulation) for sensitive skin type was confirmed. Immediate effectivity is expected. Reducing effect on discomfort upon application of cosmetics due to temporary poor skin conditions is also expected.

In vitro data

Anti-inflammation
  • Inhibitory effect on PGE2 production
  • Inhibitory effect on hyaluronidase activity
For sensitive skin
  • Inhibitory effect on NGF mRNA expression increase
  • Promoting effect on Sema3A mRNA expression
Moisture / Improvement skin barrier function
  • Promoting effect on involucrin production
  • Promoting effect on transglutaminase-1 production

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