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SAXIFRAGA STOLONIFERA
EXTRACT (B)-BG

Lightening Lightening Anti-aging Anti-aging Hair care Hair care Anti-acne Anti-acne Pore care Pore care Sensitive skin Sensitive skin Japan origin Japan origin Clinical data Clinical data HALAL HALAL COSMOS COSMOS

Clearing acne, bringing smilesAddressing consumers’ acne concerns & feelings

  • SAXIFRAGA STOLONIFERA EXTRACT (B)-BG

    Recommended for all consumers with acne concerns. Verifying the preventing effect on acne as well as increasing positive feelings.

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Mechanism

Multiple effects of SAXIFRAGA STOLONIFERA EXTRACT (B)-BG on acne

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Product information

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Product name SAXIFRAGA STOLONIFERA EXTRACT (B)-BG
Scientific name Saxifraga stolonifera (= S. sarmentosa)
Plant name (Japanese) ユキノシタ（雪の下）、コジソウ（虎耳草）
Part of use Whole part
INCI JSQI name IECIC 2021 CAS#
Saxifraga Sarmentosa Extract ユキノシタエキス 草莓虎耳草（SAXIFRAGA SARMENTOSA）提取物 164288-53-3
Butylene Glycol 1,3- ブチレングリコール 丁二醇 107-88-0
Water 水 水 7732-18-5

Study

Clinical data

Very high and visible effects against acne were confirmed by the application of lotion containing 1% SAXIFRAGA STOLONIFERA EXTRACT (B)-BG.
  • Improvement of both white & red acne as quantified by a dermatologist
  • Improvement of skin moisturizing & barrier function
  • As acne & skin condition was improved, self-confidence & sociability were positively changed (Skindex-16)
  • Volunteers realized their skin condition was greatly improved (VAS)

In vitro data

Anti-inflammation
  • Suppressing effect on TLR2 mRNA expression
Preventing acne formation & worsening by free fatty acids
  • Preventing effect on lipase activity derived from C. acnes
  • Suppressing effect on free fatty acid-induced upregulation of inflammation-related gene expression
  • SOD like activity
  • DPPH radical scavenging activity
  • Promoting effect on glutathione production
Combination effect with DIPOTASSIUM GLYCYRRHIZINATE
  • Suppressing effect on free fatty acid-induced inflammation
Importance of skin moisturization & barrier function
  • Promoting effect on hyaluronan synthase-3 mRNA expression
  • Promoting effect on aquaporin-3 mRNA expression
  • Promoting effect on claudin-1 production
  • Promoting effect on occludin production
  • Promoting effect on epidermal keratinocytes proliferation
  • Promoting effect on β-defensin 3 mRNA expression
Post-acne care
  • Inhibitory effect on melanin uptake
  • Maintaining of the dermal extracellular matrix
  • Promoting effect on fibroblast proliferation
  • Inhibitory effect on AGEs formation
  • Promoting effect on AGEs decomposition

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